Glutamate microinjection into the hypothalamic paraventricular nucleus attenuates ulcerative colitis in rats
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چکیده
منابع مشابه
Exercise training attenuates renovascular hypertension partly via RAS- ROS- glutamate pathway in the hypothalamic paraventricular nucleus
Exercise training (ExT) has been reported to benefit hypertension; however, the exact mechanisms involved are unclear. We hypothesized that ExT attenuates hypertension, in part, through the renin-angiotensin system (RAS), reactive oxygen species (ROS), and glutamate in the paraventricular nucleus (PVN). Two-kidney, one-clip (2K1C) renovascular hypertensive rats were assigned to sedentary (Sed) ...
متن کاملMicroinjection of ANG II into paraventricular nucleus enhances cardiac sympathetic afferent reflex in rats.
The aims of present study were to determine whether angiotensin II (ANG II) in the paraventricular nucleus (PVN) is involved in the central integration of the cardiac sympathetic afferent reflex and whether this effect is mediated by the ANG type 1 (AT(1)) receptor. While the animals were under alpha-chloralose and urethane anesthesia, mean arterial pressure, heart rate, and renal sympathetic n...
متن کاملIncreased Cyclooxygenase-2 Expression in Hypothalamic Paraventricular Nucleus in Rats
We investigated the role of nuclear factor B (NFB) in the cytokine-mediated induction of cyclooxygenase-2 activity in the paraventricular nucleus of hypothalamus (PVN), a critical cardiovascular and autonomic center, in rats with heart failure (HF). Sprague–Dawley rats underwent coronary artery ligation to induce HF or sham surgery. HF rats were treated orally for 6 weeks with vehicle (tap wate...
متن کاملGlutamate receptors in the hypothalamic paraventricular
22 The sympathoexcitatory response to insulin is mediated by neurons in the arcuate 23 nucleus (ARC) and hypothalamic paraventricular nucleus (PVH). Previous studies have 24 reported that stimulation of ARC neurons increases sympathetic nerve activity (SNA) 25 and arterial blood pressure (ABP) through glutamate receptor activation in the PVH. 26 Therefore, the purpose of the present study was t...
متن کاملMicroinjection of glycine into the hypothalamic paraventricular nucleus produces diuresis, natriuresis, and inhibition of central sympathetic outflow.
Strychnine-sensitive glycine receptors and glycine-immunoreactive fibers are expressed in the hypothalamic paraventricular nucleus (PVN), yet the functional significance of this innervation is unclear. Therefore, these studies examined the changes in cardiovascular and renal function and renal sympathetic nerve activity (RSNA) produced by the microinjection of glycine (5 and 50 nmol) into the P...
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ژورنال
عنوان ژورنال: Acta Pharmacologica Sinica
سال: 2013
ISSN: 1671-4083,1745-7254
DOI: 10.1038/aps.2013.140